The burden of glaucoma in a tertiary hospital, Jos, Plateau State, North Central Nigeria

Authors

  • Keziah Nanier Malu Author
  • Mercy Onevoza Adejoh Author

Keywords:

Glaucoma, late presentation, medical management

Abstract

Global glaucoma prevalence is projected to reach 111 million by 2040. In Nigeria, it remains the primary cause of irreversible blindness. Late presentation is often driven by the disease's asymptomatic, gradual onset, coupled with low public awareness and financial constraints. This study assessed the clinical presentation and management of glaucoma patients at a tertiary eye clinic. A retrospective, hospital-based descriptive study was conducted on 446 patients newly diagnosed with glaucoma between 2018 and 2019.The mean age of participants was 55.9 years, with a male-to-female ratio of approximately 1.5:1 (59.6% male). Patients over age 40 comprised 79.8% of the cohort. Alarmingly, 17.5% presented with bilateral blindness, and 35.2% of all eyes were blind at first presentation. Primary open-angle glaucoma (POAG) was the predominant type (89.9%), followed by glaucoma suspects (5.6%), secondary glaucoma (2.7%), and primary angle-closure glaucoma (1.8%). Severe structural damage was evident, with 58.7% of eyes showing a vertical cup-to-disc ratio (VCDR)0.9, and 22.6% exhibiting VCDR asymmetry 0.2. Regarding management, 94.6% opted for medical therapy while only 1.5% underwent surgery. Beta-blockers (73.7%) and prostaglandin analogues (18.4%) were the primary medications prescribed. The study highlights a significant glaucoma burden characterized by advanced disease at presentation and a high prevalence of POAG. The findings underscore an urgent need for public enlightenment and subsidized screening programs to facilitate early detection and prevention of irreversible vision loss.

Author Biographies

  • Keziah Nanier Malu

    College of Medicine and Allied Health Sciences Jos, Nigeria.

  • Mercy Onevoza Adejoh

     College of Medicine and Allied Health Sciences Jos, Nigeria.

References

1. Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology 2014; 121:2081-90.

2. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 2006; 90:262-7.

3. Kyari F, Gudlavalleti MV, Sivsubramaniam S, Gilbert CE, Abdull MM, Entekume G, et al. Prevalence of blindness and visual impairment in Nigeria: The National blindness and visual impairment study. Invest Ophthalmol Vis Sci 2009; 50:2033-9.

4. Cook C. Glaucoma in Africa: Size of the problem and possible solutions. J Glaucoma 2009; 18:124-8.

5. Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. Br J Ophthalmol 2012; 96:614-8.

6. Bastawrous A, Burgess PI, Mahdi AM, Kyari F, Burton MJ, Kuper H. Posterior segment eye disease in sub-Saharan Africa: Review of recent population-based studies. Trop Med Int Health 2014; 19:600-9.

7. Tielsch JM, Sommer A, Katz J, Royall RM, Quigley HA, Javitt J. Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore eye survey. JAMA 1991; 266:369-74.

8. Kosoko-Lasaki O, Gong G, Haynatzki G, Wilson MR. Race, ethnicity and prevalence of primary open-angle glaucoma. J Natl Med Assoc 2006; 98:1626-9.

9. Chen PP. Risk and risk factors for blindness from glaucoma. Curr Opin Ophthalmol 2004; 15:107-11.

10. Omoti AE, Osahon AI, Waziri-Erameh MJ. Pattern of presentation of primary open-angle glaucoma in Benin City, Nigeria. Trop Doct 2006; 36:97-100.

11. Susanna R Jr., De Moraes CG, Cioffi GA, Ritch R. Why do people (still) go blind from Glaucoma? Transl Vis Sci Technol 2015; 4:1.

12. Liu Y, Allingham RR. Molecular genetics in glaucoma. Exp Eye Res. 2011; 93: 331– 339.

13. Ramdas WD, van Koolwijk LM, Ikram MK, et al. A genome-wide association study of optic disc parameters. PLoS Genet. 2010; 6: e1000978.

14. Yutao Liu, Michael A Hauser, Stephen K Akafo, Xuejun Qin, Shiro Miura. Et al. Investigation of Known Genetic Risk Factors for Primary Open Angle Glaucoma in Two Populations of African Ancestry. Invest Ophthalmol Vis Sci. 2013 Sep 17;54(9):6248–6254.

15. Olawoye O, Young BP, Nyunt AW, Fafowora OF, Ajani M, Sarimiye T. Et al. Prevalence of Myocilin Mutation in a Cohort of Patience with Juvenile Open Angle Glaucoma from SubSaharan Africa.Ophthalmol Glaucoma. 2025 SepOct;8(5):450-456.

16. Verma SS, Gudiseva HV, Chavali VRM, Salowe RJ, Bradford Y, Weinreb R. Et al. A multi-cohort genome-wide Association Study in African ancestry individuals reveals loci for primary openangle glaucoma. Cell. 2024 Jan 18;187(2):464480.

17. Fox AR, Fingert JH. Familial normal tension glaucoma genetics. Prog Retin Eye Res. 2023; 96:101191.

18. Ashaye A, Ashaolu O, Komolafe O, Ajayi BG, Olawoye O, Olusanya B, et al. Prevalence and types of glaucoma among an indigenous African population in South Western Nigeria. Invest Ophthalmol Vis Sci 2013; 54:7410-6.

19. Budenz DL, Barton K, Whiteside-de Vos J, Schiffman J, Bandi J, Nolan W, et al. Prevalence of

Downloads

Published

2026-05-07

How to Cite

The burden of glaucoma in a tertiary hospital, Jos, Plateau State, North Central Nigeria. (2026). Journal of Biomedical Research and Clinical Practice, 9(1). https://jmbrcp.org/index.php/jbrcp/article/view/3